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2 edition of Selected abstracts on effects of hyperthermia on neoplasms and normal tissues found in the catalog.

Selected abstracts on effects of hyperthermia on neoplasms and normal tissues

George M. Hahn

Selected abstracts on effects of hyperthermia on neoplasms and normal tissues

by George M. Hahn

  • 366 Want to read
  • 38 Currently reading

Published by U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Technical Information Service [distributor] in Bethesda, MD, Springfield, Va .
Written in English

    Subjects:
  • Fever -- Abstracts.,
  • Heat -- Physiological effect -- Abstracts.

  • Edition Notes

    Other titlesEffects of hyperthermia on neoplasms and normal tissues.
    StatementG.M. Hahn.
    GenreAbstracts.
    SeriesOncology overview
    ContributionsInternational Cancer Research Data Bank.
    The Physical Object
    Paginationix, 92 p. ;
    Number of Pages92
    ID Numbers
    Open LibraryOL17562034M

    @article{osti_, title = {Single dose x irradiation and concomitant hyperthermia on a murine fibroscarcoma. [Sensitizing effects of hyperthermia on tumors in mice subjected to local radiotherapy]}, author = {Hahn, E W and Alfieri, A A and Kim, J H}, abstractNote = {The objectives of this study were to quantitate the effects of local tumor hyperthermia (LTH) and concomitant x irradiation. Cytocidal effects of misonidazole, Ro , and RSU on euoxic and hypoxic BP-8 murine sarcoma cells at normal and elevated temperatures Cancer, Vol. 63, No. 8 Rationale for use of local hyperthermia with radiation therapy and selected anticancer drugs in .

    In hyperthermic isolated limb perfusion (HILP) neurotoxicity is an often-mentioned side effect, this is in spite of the fact that in all studies a relatively mild hyperthermic temperature is used that, based on the experimental studies, should be well tolerated by the nerves and other normal tissues in the limbs. @article{osti_, title = {Hyperthermia and the therapy of malignant tumors}, author = {Streffer, C}, abstractNote = {Recent biological research with cells in vitro and experimental tumors shows that hyperthermia has an important role to play in cancer therapy. Hyperthermia induces a number of physiological and biological changes whereby damage is higher in the tumor than in the normal.

    abstract = "Fractionation is a radiotherapeutic “modality” that may be manipulated to attempt to improve control of malignant tumors or to decrease effects on normal tissues. In addition, some fractionation regimen must be selected as the basis for addition of any other modality such as radiosensitizers or hyperthermia.   Hyperthermia uses heat to damage and kill cancer cells without harming normal cells. It may be used for: A small area of cells, such as a tumor; Parts of the body, such as an organ or limb; The whole body ; Hyperthermia is almost always used together with radiation or chemotherapy. There are different types of hyperthermia.


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Selected abstracts on effects of hyperthermia on neoplasms and normal tissues by George M. Hahn Download PDF EPUB FB2

Get this from a library. Selected abstracts on effects of hyperthermia on neoplasms and normal tissues. [George M Hahn; International Cancer Research Data Bank.; Cancer Information Dissemination and Analysis Center for Virology, Immunology, and Biology.;].

Author(s): Hahn,George M,; International Cancer Research Data Bank.; Cancer Information Dissemination and Analysis Center for Virology, Immunology, and Biology.

Title(s): Selected abstracts on effects of hyperthermia on neoplasms and normal tissues/ G.M. Hahn, consulting reviewer. The effects of hyperthermia on pH, local blood flow (LBF) and tissue oxygen tension (TpO2) in several normal and tumor tissues were studied.

It was found that TpO2, local blood flow and pH are inhomogeneous in tumor tissue. TpO2 is very low in certain areas which also seem deprived of blood flow and are at very low by: Song CW () Effect of hyperthermia on vascular functions of normal tissues and experimental tumors: brief communication.

JNCI – PubMed Google Scholar Song CW, Kang MS, Rhee JG, Levitt SH () The effect of hyperthermia on vascular function, pH, and cell by: Perfusion techniques can cause tissue swelling, blood clots, bleeding, and other damage to the normal tissues in the perfused area; however, most of these side effects are temporary.

Whole-body hyperthermia can cause more serious side effects, including cardiac and vascular disorders, but these effects are uncommon (1, 3, 7). Apoptosis in tumor and normal tissues was examined in rats treated with whole-body hyperthermia (WBH; degrees C for 2 h).

WBH alone produced day of tumor growth delay (TGD) in a. Hyperthermia is a therapy that consists of heating the lesion site to treat tumors based on the differential response of tumor tissue and normal tissue to heat. 3, 4 Blood vessels in the tumor are. Song CW, Rhee JG, Levitt SH (c) Blood flow in normal tissues and tumors during hyperthermia.

J Natl Cancer Inst – PubMed Google Scholar Song CW Patten MS, Rhee JG, Levitt SH (a) Effect of multiple heating on the blood flow in RIF-1 tumors, skin and muscle of C3H mice. Local hyperthermia. Local HT is devoted to relatively small tumors (≤3 cm up to 5–6 cm), 6,13 located superficially or within an available body cavity such as the rectum or esophagus.

In local HT, superficial, intraluminal applicators can be applied and, most frequently, microwaves, radio waves, or ultrasound are used to convey heat to the tumors.

Abstract. Hyperthermia as a modality for the treatment of malignant tumors, either alone or in combination with radiation or anticancer drugs, is rapidly becoming a clinical reality. Three different mechanisms of action have provided the rationale for considering the use of hyperthermia.

Request PDF | Effects of Tumor Microenvironment on Hyperthermia, Photodynamic and Nanotherapy | A tumor mass is an association of normal cells and epigenetically modified cells in continuous.

The combination of immunotherapy with hyperthermia for treating cancer, however, is a particularly intriguing notion, as significant clinical effects of hyperthermia have been attributed to the immune system.

The accepted view of the cancer-host immune interface is that tumors possess unique antigens that can be recognized by the immune system.

This is a brief review of the major pathological alterations produced by hyperthermia in normal tissues of humans and other mammals. Whole-body hyperthermia, spontaneous or artificially induced, can produce severe lesions that have been best de scribed in humans: necropsies, of fatal cases of heatstroke or of individuals treated in the s by hyperpyrexia, have demon strated important.

Pettigrew RT, Ludgate CM, Smith AN. Proceedings: The effect of whole body hyperthermia in advanced cancer. Br J Cancer. Aug; 30 (2)– [PMC free article] Sakaguchi Y, Stephens LC, Makino M, Kaneko T, Strebel FR, Danhauser LL, Jenkins GN, Bull JM.

Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats. Abstract. This is a brief review of the major pathological alterations produced by hyperthermia in normal tissues of humans and other mammals.

Whole-body hyperthermia, spontaneous or artificially induced, can produce severe lesions that have been best described in humans: necropsies, of fatal cases of heatstroke or of individuals treated in the s by hyperpyrexia, have demonstrated.

The schematic of the effect of laser hyperthermia on a tumor is shown in Figure 1. Briefly, the laser can be adjusted to cover the tumor regions completely and achieve a specific depth.

This results in effective heat treatment of the target tissues without producing hyperthermia in the surrounding normal tissue. Unquestionably, hyperthermia has an important role in cancer therapy today.

Also, unquestionably, hyperthermia can affect the normal tissues adjacent to the treated tumor or, in the case of TBH,2 many normal tissues.

Therefore, to apply this modality judiciously one must know, and weigh, these possible deleterious effects. hyperthermia in selected parts of the body were developed. surrounding normal tissues are not exceeded External local hyperthermia is used to treat tumors that are in or just below the skin.

Hyperthermia may damage normal tissues when the tolerance limits are exceeded. Most tissues tolerate treatment of 1 hour at 43°C, only nervous and gastro-intestinal tissues appear more sensitive.

Abstract. Hyperthermia has the potential to modify the cytotoxicity of anticancer drugs and to convert some other drugs to cytotoxic agents having no considerable cytotoxicity at normal temperature. This has been demonstrated by in vitro and in vivo experiments, which.

The effect of hyperthermia on vascular function, pH, and cell survival. C W Song while that in the muscle increased. The clonogenic cell number continuously decreased when SCK tumors were left in situ after hyperthermia. The vascular occlusion and increase in acidity may account for the progressive death of tumor cells after heating.This effect of overheating of tumors was called selectivity of laser actions on the tumors.

The experiments on the experimental animals gave the results which were in a good agreement (qualitatively) with our calculations. These computer calculations of tissues heating can be used for photodynamic therapy and laser therapy also.Hyperthermia can also modify factors that are essential for tumour survival and growth, such as the microenvironment, immune responses, vascularisation and oxygen supply.

Thus, the effects of hyperthermia are multifactorial. Hyperthermia is a clinically proven successful adjuvant treatment.